Did anyone else notice something really bizarre on last night’s episode of the award-winning ABC show, “Desperate Housewives”?

Bree (Marcia Cross) was sitting at the table talking with her daughter about those strange neighbors when suddenly, quite without warning, her forehead…moved.

I’m not making this up. Cross’s forehead actually crinkled ever-so-slightly with what can only be described as slight surprise, followed by mild annoyance.

Good Lord, what’s next? A full-on furrowed brow scowl?

Concerned, I immediately called top L.A. dermatologist Joshua Wieder at UCLA. No, Marcia Cross is not his patient. In fact, he’s never even met the woman and he has no idea what, if anything, she uses on her skin to keep that calm, inscrutable look. But he knows Botox and he has an opinion on what I described.

“Botox wears off gradually and expressions, caused by muscles that become active again, do slowly return,” said Wieder. “Most of my patients need it done every five or six months but some women can only go three or four months.”

Wieder and other top L.A. skin docs are starting to use a new form of muscle paralyzer called Myobloc for patients who become resistant to Botox. Yes, I know, it's a terrifying thought. Soon there will be fund-raisers for these poor unfortunates.

Myobloc doesn’t last as long as Botox and it costs a few dollars more. Stings more too, Wieder says. But apparently, it’s really great for touch ups when one’s regular Botox has started to wear off and it's too early to get more injected.

“It’s a different strain of the botulism toxin, Type B, not Type A, so there is no cross-reaction. I use it on patients for a quick touch up when their regular Botox is wearing off slightly but isn’t completely gone,” Wieder explains. “Especially right before the Oscars.”

Nominees, take note. God forbid those reaction-shot cameras in the Kodak Theatre should catch a sour expression when the Oscar envelope is opened and the winner’s name — not yours — is read.

Photo: Marcia Cross was all smiles when she won an award for best ensemble cast in a TV comedy at the Screen Actors Guild Awards.
(Jeffrey Mayer / WireImage)